Wolfram syndrome (WFS) is a rare diffuse neurodegenerative disorder characterized by diabetes insipidus, diabetes mellitus,
optic atrophy, deafness, and a wide variety of central nervous system abnormalities. Insulin-dependent diabetes mellitus with
optic nerve atrophy is a sufficient criterion for the diagnosis. WFS is a devastating disease for the patients and their families.
This study emphasizes the need for careful evaluation of cases having insulin-dependent diabetes mellitus and optic atrophy.
The authors have stated that they do not have a significant financial interest or other relationship with any product manufacturer
or provider of services discussed in this article. The authors also do not discuss the use of off-label products, which includes
unlabeled, unapproved, or investigative products or devices.