Two patients with hepatorenal toxicity resulting from sniffing a popular spotremover containing trichloroethylene are described. These complications are uncommon when trichloroethylene is used for clinical anesthetic purposes, suggesting that the closed-circuit type of inhalation employed by sniffers, and the alcoholic consumption which frequently accompanies the habit may potentiate the toxicity of the hydrocarbon. Although glue is more commonly sniffed by teenagers, spot-remover containing trichloroethylene appears to be associated with more serious complications and is another agent to be added to the causes forhippie hepatitis.