Soft tissue loss or damage can occur for various reasons, including trauma, surgery, and disease. Reconstruction of normal contours can be achieved by using either alloplastic implants or autogenous tissues. Permacol, a dermal replacement material derived from fibrous acellular porcine dermal collagen, has been used for restoration of soft-tissue contours in the face. Eight patients were treated with porcine collagen in an attempt to achieve a smooth contour and a natural feel. Clinically visible soft tissue defects were successfully covered and aesthetic results were satisfying. Transient swelling that subsided within a week was noted in all patients. Meticulous and aseptic technique is mandatory for Permacol use. With this limited experience, Permacol was successfully used as a filler implant in reconstruction of post-traumatic soft-tissue defects, correcting post-parotidectomy hallowing and secondary nasal surgery to cover osseocartilaginous irregularities. However, there is a potential risk of inflammation and skin contractures in thin-skinned patients when implants are placed superficially.