A new system for wireless monitoring of pulse oximetry (SpO2) was developed on the basis of a Nonin OEM III oximetry module and a radiofrequency transceiver. The electronic unit and the power supply was integrated into a specially designed infant shoe named BBA bootee. Clinical evaluation of the system revealed a good agreement between the pulse oximetry data transmitted by the BBA bootee and those recorded simultaneously by a reference monitor. The comparative data collected in 39 babies yielded a mean (bias SD) value of (−1.1 1.9)% for SpO2 and (−2 8) beats per minute for heart rate. Use of an integrated accelerometer/actimeter to reduce the motion artifact is addressed as well as ergonomics of the sensor-supporting garment.