Volume 30, Number 2, 137-138, DOI: 10.1007/BF01927692

Morphine tolerance in a human neuroblastoma line: Changes in choline acetylase and cholinesterase activities

G. Manner, F. F. Foldes, Marilyn Kuleba and Ann M. Deery

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Abstract

Nachweis der Entstehung einer Morphin-Toleranz und-Dependenz sowie von Veränderungen (Steigerung der Cholinesterase, Verminderung der Cholin-o-Acetyltransferase) von Enzymaktivitäten nach länger dauernden Morphingaben bei Neuroblastom-Kulturen.

Acknowledgements. This work was supported by grant No. U-2270 from the Health Research Council of the City of New York, a Lucy G. Moses Fellowship and an Irma T. Hirschl Career Scientist Award (to G.M.)

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