The aim of this paper is to investigate the clinical features and transformation of elderly male patients with normal blood
glucose levels at fasting and 2 hours after glucose intake but with hyperglycemia (⩾ 11.1 mmol/L) 1 hour after oral glucose
tolerance test (OGTT-1h HG). Seven years of follow-up visits were performed on 189 elderly male outpatients with OGTT-1h HG
and data was recorded on their body mass index (BMI), blood pressure, serum cholesterol and triglyceride test results and
on their glucose tolerance changes every 1–2 years after taking OGTT; their possible causes were analysed. Follow-up visits
revealed that 19 patients with OGTT-1h HG were diagnosed with diabetes (10.1%), 78 patients with impaired glucose tolerance
(IGT, 41.3%), 2 patients transformed to normal glucose tolerance (NGT, 1.1%) and the remaining 90 patients (47.6%) remained
unchanged. Synchronized comparison with IGT patients showed that the ratio of OGTT-1h HG patients turning to diabetes was
lower than that of IGT patients (21.1%,
χ
2 = 13.05,
P < 0.01), and the ratio of OGTT-1h HG patients transforming to NGT was slightly higher (0.4%,
χ
2 = 2.46,
P > 0.05). The prevalence of complications of hypertension, coronary heart disease, cerebral vascular diseases and dyslipidemia
in patients with OGTT-1h HGwere higher than those with NGT (
P < 0.05) and were similar to that of IGT patients. As a special phenotype of OGTT and as part of an abnormal glucose tolerance
conformation, patients with OGTT-1h HG warrant special attention, since about half of them were found to have developed diabetes
or IGT, and their risk of suffering from vascular diseases were also increased.
Keywords glucose tolerance test - clinical features - transformation
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Translated from Chinese Journal of Diabetes, 2006, 14(6): 442–445 [译自: 中国糖尿病杂志]