Intraperitoneal injection of paclitaxel (Mitotax) in a single dose of 40 mg/kg was followed by an increase in the number of
mitotic granulocytic and erythroid cells, hypoplasia, and pancytopenia of the bone marrow in CBA/CaLac mice. The test preparation
decreased the number of hematopoietic precursor cells for erythropoiesis and granulocytopoiesis, but increased the count of
polyploid cells and incidence of structural and genomic abnormalities in bone marrow cells. These changes were reversible.
Key Words paclitaxel - bone marrow - hematopoietic precursor cells - myelotoxicity - genotoxicity
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 2, pp. 173–177, February, 2008