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Original Investigations

A new motility meter based on the Doppler principle

M. Vanuytven1, 2, J. Vermeire1, 2 and C. J. E. Niemegeers1, 2   Contact Information

(1) Janssen Scientific Instruments Division, Janssen Pharmaceutical Research Laboratories, B-2340 Beerse, Belgium
(2) Department of Pharmacology, Janssen Pharmaceutical Research Laboratories, B-2340 Beerse, Belgium

Received: 31 October 1978  Accepted: 16 March 1979  

Abstract  A new motility meter for recording the locomotor activity of small laboratory animals is described in detail. The equipment is designed to record simultaneously, but independently, the motility of eight animals (or groups of animals) in separate cages. The functional mechanism is an application of the wellknown Doppler principle. The use of electromagnetic waves presents the important advantages of contactless detection and freedom from interference of external stimuli with spontaneous activity; both horizontal and vertical components of movement are registered. To test the equipment, motility was studied in rats treated with saline, haloperidol, d,l-amphetamine, and the combination of haloperidol and d,l-amphetamine. Motility, as measured with the Doppler motility meter, proved to be very sensitive to drug-effects.

Key words  Motility meter - Haloperidol -  d,l-Amphetamine - Rats


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Referenced by
2 newer articles

  1. Niemegeers, C. J. E. (1982) The in vivo pharmacological profile of histamine (H1) antagonists in the rat. Drug Development Research 2(6)
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  2. Awouters, Frans (1988) Pharmacological profile of ritanserin: A very specific central serotonin S2-antagonist. Drug Development Research 15(1)
    [CrossRef]
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