Nimesulide, like other NSAIDs, exhibits adverse reactions in the major organ systems comprising the upper GI tract, liver, kidney, skin and immune systems. Noteworthy is the fact that this drug has relatively low occurrences of GI ulcers and bleeding, asthma and respiratory tract reactions and does not appear to have the cardiovascular reactions (congestive heart failure, myocardial infarction) that has been observed recently with the coxibs and some other NSAIDs.