Volume 15, Number 3, 282-284, DOI: 10.1007/BF00702370

“Relatedness” between antibodies —Implications on immunogenetic systems

Jan Hirschfeld

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Abstract

A serologic model, a mathematical treatment of this model as well as experimental serologic evidence have all made it highly probable that a new type of ldquorelatednessrdquo between antibodies, (at least assumed to react with antigens within the same immunogenetic system) is a very common phenomenon.
It is shown that conventional models assuming monospecific and unrelated base reagents give rise to erroneous assumptions regarding the serologic and genetic aspects of immunogenetic systems if the base reagents are instead ldquorelatedrdquo. Thus a relation between antibodies could falsely be interpreted as being instead a relation between antigens on a serologic; genetic or biochemical level.
Die statistische Behandlung eines serologischen Modells und experimentelle serologische Ergebnisse führen zu der Annahme einer häufig vorkommenden neuartigen ldquoBeziehungrdquo zwischen Antikörpern.
Voraussagen über serologische und genetische Aspekte immunogenetischer Systeme können unter der Voraussetzung der hier postulierten ldquoBeziehungrdquo deshalb zu Irrtümern führen, weil die konventionellen Modelle monospezifische und nicht miteinander in Beziehung stehende Reagentien voraussetzen.

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