The effect of cyproheptadine, an inhibitory of serotonin and histamine, on the effects of exogenous and endogenous bradykinin was investigated. Cyproheptadine inhibited the effect of bradykinin on a segment of guinea pig intestine in vitro, abolished the hypotensive action of bradykinin on rats in vivo, and blocked constriction of the blood vessels of the rabbit ear and the fall in the blood kininogen level caused by injection of pyrogenal.
Key Words bradykinin - action block - cyproheptadine
Academic Group of Academician of the Academy of Medical Sciences of the USSR the late P. E. Lukomskii, Institute of Normal and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. M. Chernukh.) Translated from Byulleten'' Éksperimental''noi Biologii i Meditsiny, Vol. 80, No. 7, pp. 6–9, July, 1975.