The objects of the investigation were to study the role of uv radiation in distant intercellular interactions (DII) and the conditions for obtaining a
mirror
cytopathic effect (MCPE). An extremal state of the cells in the radiating culture caused by uv-radiation was shown to induce a distant cytopathic effect (CPE) in an intact detector culture in optical contact only with it, reflecting the specific character of the morphological features recorded in the affected culture. Preliminary uv-irradiation of the detector cells facilitates manifestation of the MCPE.
Key Words distant intercellular interactions - mirror cytopathic effect - uv radiation - cell culture
Laboratory of Biophysics, Institute of Clinical and Experimental Medicine, Siberian Branch, Academy of Medical Sciences of the USSR, Novosibirsk. Translated from Byulleten'' Éksperimental''noi Biologii i Meditsiny, Vol. 87, No. 5, pp. 468–471, May, 1979.