The authors report a case of therapy-related acute promyelocytic leukemia (t-APL), with typical cytogenetic translocation t(15;17), which appeared following chemotherapy (ABVD), and radiotherapy for Hodgkin's disease (IIB). After treatment with all-trans retinoic acid (Vesanoid^® 45 mg/m² daily) complete remission of t-APL was achieved. Then only one course of chemotherapy ‘3+7’ (doxorubicin 45 mg/m² 1–3 d, cytosar 200 mg/m² 1–7d) was applied and the patient interrupted further treatment in July 1994. Four years later she had a normal pregnancy and delivered a healthy female infant in December 1998.