Purpose
We compared the pharmacokinetics of chloroquine in pregnant and nonpregnant women treated for Plasmodium vivax malaria.
Methods
Twelve pregnant women and 15 nonpregnant women of child-bearing age with acute P. vivax malaria were treated with 25 mg chloroquine base/kg over 3 days on the northwestern border of Thailand. Blood concentrations
of chloroquine and desethylchloroquine were measured using hydrophilic interaction liquid chromatography coupled with fluorescence
detection. Twenty-five women completed the pharmacokinetic study.
Results
Although increasing gestational age was associated with reduced chloroquine
\textAUC0 ® ¥ {\text{AUC}}_{0 \to \infty } , there was no significant difference overall in the pharmacokinetics of chloroquine between pregnant and nonpregnant women.
Fever was associated with lower chloroquine
\textAUC0 ® ¥ {\text{AUC}}_{0 \to \infty } values. Desethylchloroquine area under the curve (AUC) values were not significantly affected by pregnancy.
Conclusions
Pregnancy did not significantly affect blood concentrations of chloroquine or its metabolite, desethylchloroquine, in women
with P. vivax malaria.
Keywords Malaria -
Plasmodium vivax
- Chloroquine - Pharmacokinetics - Pregnancy