This paper elucidates and discusses some aspects of cultural adaptability which aid usability and universal access. We describe the concept, influence and Use Cases of cultural adaptability in driver information and assistance systems exemplified by a portable navigation system. Thereby, the reasons, advantages and problems of using adaptability regarding the driving safety and the driver preferences will be addressed. Differences in the amount of information for map display and in interaction behavior which depend on the cultural background of the users (e.g. attitude, preference, skill etc.). We explain how cultural adaptability can improve usability and how it has a share in universal access. Finally, a short outlook into the future of adaptive driver information and assistance systems closes our reflections.