Objectives: This study explores several factors potentially associated with reduced fecundability among women working in cut flowers production. Methods: A cross-sectional study of first pregnancies was undertaken in 47 Colombian floriculture companies. Two thousand and eighty-five women were interviewed regarding potential reproductive, lifestyle and work history predictors of time-to-pregnancy (TTP), measured in months. Fecundability odds ratios (fOR) were estimated using a discrete time analogue of Coxs proportional hazard model. Results: Associated with longer TTP were: irregular relationships with her partner (fOR 0.82, 95% CI 0.73–0.91), illness in the year prior to pregnancy (fOR 0.78, 95% CI 0.62–0.98), smoking tobacco (fOR 0.71, 95% CI 0.59–0.85), and work in flower production, less than 24 months (fOR 0.86 95% CI 0.75–0.98) or 2 years or more (fOR 0.73, 95% CI 0.63–0.84). Conclusions: Work in flower production, irregular relationship, illness and tobacco exposure would be associated with impaired fecundability.