Self-hardening calcium deficient hydroxyapatite/gelatine foams for bone regeneration

Edgar B. Montufar, Tania Traykova, Etienne Schacht, Luigi Ambrosio, Matteo Santin, Josep A. Planell and Maria-Pau Ginebra

From the issue entitled "Special Issue: Selected papers from the 22nd European Conference on Biomaterials, Lausanne, Switzerland, September 2009; Guest Editors: Christine Wandrey, Marc Bohner and Geoff Richards"

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Abstract

In this work gelatine was used as multifunctional additive to obtain injectable self-setting hydroxyapatite/gelatine composite foams for bone regeneration. The foaming and colloidal stabilization properties of gelatine are well known in food and pharmaceutical applications. Solid foams were obtained by foaming liquid gelatine solutions at 50°C, followed by mixing them with a cement powder consisting of alpha tricalcium phosphate. Gelatine addition improved the cohesion and injectability of the cement paste. After setting the foamed paste transformed into a calcium deficient hydroxyapatite. The final porosity, pore interconnectivity and pore size were modulated by modifying the gelatine content in the liquid phase.

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