Achalasia is the best described motor disorderof the esophagus. Associations with familialglucocorticoid deficiency and alacrima (triple Asyndrome) have been described in the pediatricpopulation, but no attention has been paid to the possibilityof this association in adults. Tear production wasassessed in 20 patients with achalasia and 20 age- andsex-matched controls. Deficient tears were found in four achalasics compared with none among thecontrols (P < 0.05).="" this="" suggests="" that="" some="" variantof="" the="" triple="" a="" syndrome="" (achalasia,="" alacrima,="" andadrenocortical="" insufficiency)="" may="" exist="" in="" adultpatients="" with="" achalasia="" as="">