Optical coherence tomography (OCT) is a non-invasive, transpupillary imaging technology that allows detailed analysis of the retinal structures. In a recent article, Gualino et al. reported that OCT revealed a foveolar cystoid space with focal disruption of the photoreceptors line that explains the irreversible loss of central vision in tamoxifen retinopathy. In addition to providing a better understanding of the pathogenesis of tamoxifen retinopathy, OCT screening is advisable in patients treated with tamoxifen over long periods in order to detect and prevent drug-induced retinal damage.