Hydrogels have been successfully used in several biomedical applications, such as controlled drug release and micro-patterning. More recently, the ability to engineer composite hydrogels has generated new opportunities in addressing challenges in tissue engineering as well as in tissue function restoration via prostheses. Indeed, the knowledge of biocompatible materials and preparation technologies may be efficaciously used in synthesizing biocompatible hydrogels to develop state-of-the-art hydrogel-based devices for tissue regeneration and reconstruction. Important details with respect to the design of the materials adopted and with respect to specific tissues, such as tendons and ligaments, intervertebral discs, bone, menisci, and cartilage will be discussed.