Various problems concerning the pharmaceutical and personal care products (PPCPs) in the environment of the Eastern European countries are described. The main classes of PPCPs in the environment, as well as major occurrence pathways and PPCPs fate, are depicted. The influence of specifics of the regional pharmaceutical market, medication consumption culture and pharmaceutical waste disposal techniques on environmental pollution with PPCPs, are discussed. Examples of wrong drugs prescription, drugs misuse, drugs overconsumption, and poor pharmaceutical waste management are presented. The necessity in research and management of PPCPs with emphasize on the local specifics and practices are concluded.