We present a novel framework for exploring very large state spaces of concurrent reactive systems. Our framework exploits application-independent heuristics using genetic algorithms to guide a state-space search toward error states. We have implemented this framework in conjunction with VeriSoft, a tool for exploring the state spaces of software applications composed of several concurrent processes executing arbitrary code. We present experimental results obtained with several examples of programs, including a C implementation of a public-key authentication protocol. We discuss heuristics and properties of state spaces that help a genetic search detect deadlocks and assertion violations. For finding errors in very large state spaces, our experiments show that a genetic search using simple heuristics can significantly outperform random and systematic searches.