There are many Molecular Biology Databases, also known as Genome Databases, and there is a need for integrating all this data sources and related applications. This work proposes the use of an object-oriented framework for genome data access and manipulations. The framework approach is an interesting solution due to the flexibility, reusability and extensibility requirements of this application domain. We give a formal definition of our Genome Databases Framework using UML class diagrams, that explore the structural part of the architecture. A brief discussion on the Framework functionalities is also presented.