Volume 24, Number 7, 1494-1498, DOI: 10.1007/BF00946421

Synthesis of protected collagen-type oligopeptides with -Gly-Pro-Pro- and-Gly-Pro-Ala- sequences and their structural characteristics

V. A. Shibnev, V. S. Grechishko, M. P. Finogenova, V. V. Kobyakov and V. M. Lobachev

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Abstract

1.  The method of mixed anhydrides was used to synthesize some protected oligopeptides of the collagen type: Cbo-(Gly-Pro-Pro)n-OCH3, where n=1–8, and Cbo-(Gly-Pro-Ala)n-OCH3, where n=1–4.
2.  Employing x-ray structure analysis and IR spectroscopy it was shown that a three-spiral structure of the collagen type is formed spontaneously in the sequence -Gly-Pro-Pro-when n=4.
Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 7, pp. 1608–1612, July, 1975.
The authors express their gratitude to V. N. Rogulenkova and N. G. Esipova for taking the x-ray patterns.

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