Twenty depressed patients given 150 mg of imipramine nightly improved as well as twenty depressed patients given imipramine in three daily doses of 50 mg. An earlier improvement was noted on the single dose schedule, whereas a better long-term effect was suggested for the divided dosage. No unusual toxicity or side effects were connected with the single dose schedule.
Key words Depression - Anti-Depressants - Imipramine - Dosage