With the steady increase of non-European, non-English speaking immigrants to the United States, the relationship between acculturation and risk for cardiovascular disease (CVD) is an issue of growing importance to researchers interested in the health of new immigrant populations. The influence of acculturation processes on adverse changes in blood pressure (BP), a major risk factor for CVD, has been examined in Hispanic-Americans and Asian-Americans. Published studies on this relationship in Arab-Americans are lacking, however, despite their growing numbers. With a specific focus on Chaldean-Americans, a major subgroup of the large Arab-American population located in metropolitan Detroit, Michigan, the current study investigates the influence of level of acculturation on BP in a community probability sample of 130 Chaldean-American women. Study participants were interviewed in their homes (92% response rate). Physical measurements included BP, body mass index (BMI), and waist–hip ratio. Demographic and acculturation data were obtained through a standardized questionnaire. The crude hypertension prevalence in the sample was 16%. Three dimensions of acculturation were identified through content and factor analysis: English language preference, parental school involvement, and ethnic identity. In unadjusted analyses, both English language preference and Chaldean-American ethnic identity were associated (p < 0.01)="" with="" lower="" mean="" bp,="" but="" these="" differences="" became="" nonsignificant="" when="" age,="" bmi,="" and="" waist–hip="" ratio="" were="" statistically="" controlled.="" parental="" school="" involvement="" was="" not="" associated="" with="" bp="" in="" any="" analyses.="" in="" this="" study,="" the="" strongest="" predictors="" of="" bp="" were="" bmi="" and="" waist–hip="" ratio,="" both="" of="" which="" were="" inversely="" correlated="" with="" age,="" education,="" english="" language="" preference,="" employment="" outside="" the="" home,="" and="" parental="" school="" involvement.="" future="" studies="" of="" acculturation="" and="" bp="" in="" chaldean-americans="" (and="" other="" arab-american="" populations)="" should="" use="" improved="" measures="" of="" acculturation,="" broader="" assessments="" of="" behavioral="" and="" socioeconomic="" status,="" and="" larger="" samples="" that="" includes="" both="">