Volume 25, Number 5, 382-383, DOI: 10.1007/BF00686244

Complete remission of brain metastases of ovarian cancer following high-dose carboplatin: a case report and pharmacokinetic study

L. Thomas Vlasveld, Jos H. Beynen, Willem Boogerd, Willem W. Bokkel Huinink and Sjoerd Rodenhuis

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Abstract

Brain metastases developed in a 40-year-old woman with relapsed ovarian cancer 2 years after cisplatin-based combination chemotherapy. After a single dose of 800 mg/m2 carboplatin, complete remission of the brain metastases occurred. A pharmacokinetic study during the second course revealed low levels of carboplatin in the cerebrospinal fluid.

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