Perfusion experiments were carried out in the proximal jejunum and in the distal ileum of conscious rats, using a newly devised technique. The stimulation effect of actively transported hexoses on the sodium, potassium and fluid absorption is demonstrated.
| 1. |
There are quantitative differences concerning the effect of 3-O-methyl-d-glucose andd-glucose on the sodium and water absorption.
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| 2. |
The stimulation by glucose can be seen only when the glucose concentration in the luminal fluid is greater than 10 mM.
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| 3. |
The ratio of 3-O-methyl-d-glucose- to sodium-transfer-rate is >1, while it is exactly 1 in the experiments involvingd-glucose.
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| 4. |
The sodium-water equivalent is isotonic under all experimental conditions.
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| 5. |
In the presence of actively transported hexoses the secretion of potassium into an initially K+-free perfusate is significantly diminished.
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| 6. |
The transport of potassium depends on the net fluid movement.
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| 7. |
The stimulation of glucose and 3-O-methyl-d-glucose can only be demonstrated in the jejunum of rat whereas no effect is seen in the distal ileum and colon.
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| 8. |
These results suggest that  solvent drag isone factor which under the above mentioned experimental conditions affects the enhanced electrolyte and water absorption in the jejunum of the rat.
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Key words Intestinal Water and Electrolyte Absorption - Effect of Actively Transported Hexoses - Conscious Rats