The role of the gut immune system in the development of autoimmune m type 1 diabetes is evaluated in this review with special
emphasis in the hypothesis suggesting that dietary cow’s milk insulin could trigger betacell autoimmunity when the mechanisms
of oral tolerance are disturbed.
Key words type 1 diabetes - insulin - gut - beta-cell autoimmunity - alpha4beta7-integrin - cytokines - breast milk - microflora - enterovirus