The possibility of obtaining paracetamol (4-acetamidophenol) and oxaphenamide (4-hydroxyphenylsalicylamide) by means of a single-stage reductive acylation of 4-nitrophenol on palladium catalysts has been studied. Using this single-stage reaction under mild conditions (organic solvents; temperature, 45°C; hydrogen pressure, 1 bar) the target compounds were obtained with a yield of 70–90% for paracetamol and 41–63% for oxaphenamide. Metal — polymer catalyst systems have proved to be more active and selective than the traditional heterogeneous Pd/C catalysts.