Associative memories based on DNA-affinity have been proposed [2]. Here, the performance, efficiency, reliability of DNA-based memories is quantified through simulations in silico. Retrievals occur reliably (98%) within very short times (milliseconds) despite the randomness of the reactions and regardless of the number of queries. The capacity of these memories is also explored in practice and compared with previous theoretical estimates. Advantages of implementations of the same type of memory in special purpose chips in silico is proposed and discussed.