Purpose
Choroidal neovascularization (CNV) secondary to traumatic rupture of Bruch’s membrane is a rare condition, without standardized
treatment. Here we describe one case of CNV related to traumatic rupture of Bruch’s membrane which was successfully treated
with intravitreal injection of ranibizumab.
Methods
A 14-year-old patient was referred for ocular contusion, complicating interpapillomacular rupture of Bruch’s membrane in left
eye. Indeed, a correct initial visual acuity, juxtafoveolar CNV appeared 4 months later on the border of Bruch’s membrane
rupture. The patient was treated with an off-label intravitreal ranibizumab because of worsening of visual acuity.
Results
One month after intravitreal injection, visual acuity improved, from 20/40 to 20/25. At 12-month follow-up, visual acuity
remained at 20/25, fundus examination. Fluorescein angiography, indocyanine green angiography and optic coherence tomography
showed fibrotic evolution of CNV. The Bruch’s membrane rupture remained stable. No side-effect of intravitreal injection of
ranibizumab was observed.
Conclusion
For this patient affected with CNV secondary to traumatic Bruch’s membrane, one single intravitreal ranibizumab injection
was efficient, with 1-year follow-up.
Keywords Intravitreal ranibizumab - Lucentis - Bruch’s membrane rupture - Choroidal neovascularization
The authors have no proprietary interest in the materials used in this study.