Volume 25, Number 10, 737-743, DOI: 10.1007/BF01345291

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Gastroenterology Research Group

Effect of ranitidine, a new H2-antagonist, on gastric and pancreatic secretion in duodenal ulcer patients

Stanislaw J. Konturek, Wojciech Obtulowicz, Nina Kwiecień, Edward Sito, Jan Oleksy and Barbara Miszczuk-Jamska

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Abstract

The effects of a new H2-receptor blocker, ranitidine, given intravenously (for comparison with cimetidine) or orally on gastric and pancreatic secretion have been studied in duodenal ulcer patients. Ranitidine appears to be several times more potent and a longer-acting inhibitor of gastric secretion than cimetidine. This H2 blocker does not affect pancreatic bicarbonate and enzyme secretion.

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