■ Noninfectious uveitides are systemic (auto)immune disorders mediated by activation of antigen-specific T-lymphocytes and,
in the main, tissue destruction orchestrated by nonspecific mononuclear cells. Disease remission is achieved by systemic immunosuppression,
whilst control of chronic ocular inflammation can be achieved by a local or systemic suppression of the immune response.
■ Given current evidence, the clinical efficacy of immunosuppressive and immunomodulatory drugs underlines their role as a
first-line therapy for uveitis.
■ Vitrectomy is indicated in patients with uveitis to manage complications and improve visual acuity. There is only scant
evidence supporting a therapeutic effect of vitrectomy for noninfectious uveitis.
■ Vitreous opacities in patients with Fuchs uveitis syndrome and intermediate uveitis refractory to medical treatment are
indications for a therapeutic vitrectomy.