The time elapsed between the first onset of symptoms and the onset of first hospitalisation was analysed in 355 participants
diagnosed with paranoid, simple, hebephrenic and catatonic schizophrenia and shizoaffective disorder. The real onset of the
disease was assessed from interviews with reliable relatives and by reviewing medical records in general practices and out-patient
psychiatric services. In 184 patients a family history of schizophrenia was identified. A positive family history was found
to significantly increase the interval preceding first hospitalisation in all analysed types, except in catatonic schizophrenia.
Possible reasons causing this prolongation are discussed, as well as repercussions of the results to studies using age of
first hospitalisation as the leading indicator.
Keywords: Schizophrenia - catatonic type; schizophrenia - subtype; pre-hospitalisation interval; age of onset; first hospitalisation; family history; epidemiology; Croatia.
Received May 24, 2000; accepted October 17, 2001