Management of an unusual injury of combined open fractures of the first metacarpal shaft and trapezium due to crush injury in a 21-year-old man was reported in this paper. Surgical management included irrigation, debridement, and reduction of the first metacarpal fracture followed by external fixation extending from the first metacarpal to the distal radius and primary wound closure. After 1 year of surgery, follow-up functional and radiographic evaluations were satisfactory, and most of the daily activities were pain-free.