e-Learning as a new integrative and ubiquitous environment in academic teaching and learning opens new opportunities for students with disabilities. At the same time there are new barriers just overcome in electronic communication and interaction. The Notebook University – a model project at the Universitaet Karlsruhe (TH) experiences the different parts of a comprehensive wireless teaching and learning surrounding. The Study Center for Blind and Partially Sighted Students – as a micro project in between – focuses on the special opportunities and barriers for visually impaired students. Personal experiences, case studies and tests of assistive technology result in documentations, final recommendations and an open cooperative homepage.