Influence of ampicillin, clindamycin or metronidazole upon the 7α-dehydroxylation of bile acids in the human intestine

Karin Andréasson, K. Elisabeth Norin and Tore Midtvedt

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Abstract

The effect of ampicillin, clindamycin and metronidazole upon the 7 agr

-dehydroxylation of cholic acid by the microflora in the intestine was tested in healthy subjects. Clindamycin gave a significant decrease in the 7 agr

-dehydroxylation. With the other two antibiotics, no significant changes were seen.

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Influence of ampicillin, clindamycin or metronidazole upon the 7α-dehydroxylation of bile acids in the human intestine

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