Diabetes represents the primary cause of nontraumatic amputation in the Western World (1). It is estimated that about 25% of subjects with diabetes will experience problems over the course of their lives with their feet and that one-third of these patients will undergo amputation (2–4). Although these data highlight the extent of this problem in the diabetic population, they do not necessarily predicate inevitability: on the contrary, they serve to demonstrate that simple and relatively inexpensive measures may be able to reduce even up to 85% the number of amputations (5–9). Some clinical conditions put the patient with diabetes “at risk of ulceration.”; An awareness of these conditions and the identification of subjects at risk may permit the introduction of suitable preventive strategies (10–13).