When rat pancreatic islets were exposed for 30 min at 37°C to tritiated glibenclamide (2.5
M) or glimepiride (1.5
M), internalization of these hypoglycaemic sulphonylureas in B and non-B cells was observed by autoradiography. In the B cell, the autoradiographic grains were often associated with secretory granules.
Key words Glimepiride - Glibenclamide - Pancreatic islets