The bile-secretory function of the liver under normal conditions and in experimental atherosclerosis produced by administration of cholesterol was studied in experiments on young (3–4 months old) and adult (30–36 months old) hens of the Russian White breed. During natural aging a decrease in the total and free cholesterol concentrations in the blood serum and in the bile-secretory function of the liver was observed These indices were raised during administration of cholesterol and atherosclerotic changes developed in the aorta. The severity of these changes compared with normal was greater in the adult than in the young experimental birds.
Key Words experimental atherosclerosis - age - bile acids - cholesterol - liver
Laboratory of Pathophysiology, Institute of Gerontology, Academy of Medical Sciences of the USSR. Ukrainian Agricultural Academy. Institute of Physiology, T. G. Shevchenko Kiev University. (Presented by Academician of the Academy of Medical Sciences of the USSR N. N. Gorev.) Translated from Byulleten'' Éksperimental''noi Biologii i Meditsiny, Vol. 82, No. 9, pp. 1038–1041, September, 1976.