Elderly normal volunteers (
N=12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administration. Significant impairments were found in response to all doses of diazepam. The maximum impairment occurred at 1 h, which coincided with the highest plasma concentration of the drug.
Key words Diazepam - Benzodiazepines - Aged - Memory - Psychomotor performance - Buschke Selective Reminding Task - Plasma concentrations