This review of recent research in the state of Puebla, Mexico, focuses on six issues: (1) reevaluations of the Tehuacan Valley Archaic; (2) rural household archaeology at Tetimpa; (3) the impact of Popocatépetls eruptions; (4) the city of Cholula; (5) the Nahua-Otomangue frontier; and (6) new perspectives on the Mixteca-Puebla art style. Not only do these topics illustrate the scope of archaeological work, but they can be linked to broader anthropological themes like the origins and spread of agriculture, relationships between rural populations and emergent cities, the environmental, social, and cultural impact of natural disasters, the operation of geographical frontiers and ethnic interfaces, the construction of cultural landscapes, and the connections between political organization and art style. Pueblas location along numerous environmental and cultural divides makes it an excellent laboratory for the study of human interaction across diverse kinds of frontiers.