The intercalation of drug molecules with montmorillonit (MMT) using Acyclovir (ACV) as the model drug was focused on. The
optimum conditions were studied based on orthogonal design, such as intercalation time and temperature. The intercalation
composites were characterized by X-ray diffraction (XRD), Fourier transformed infrared (FT-IR), and thermogravimetric analysis
(TGA). The experimental results reveal that ACV is successfully intercalated into the interlayers of MMT. The
in vitro release experiments reveal that ACV is released from MMT steadily and pH dependent
Key words montmorillonite - acyclovir - intercalation -
in vitro release
Funded by the National Natural Science Foundation of China (No. 20204008)