Objectives
To (1) obtain microstructural parameters (Fractional Anisotropy: FA, Mean Diffusivity: MD) of the cervical spinal cord in
patients suffering from cervical spondylotic myelopathy (CSM) using tractography, (2) to compare DTI parameters with the clinical
assessment of these patients (3) and with information issued from conventional sequences.
Methods
DTI was performed on 20 symptomatic patients with cervical spondylotic myelopathy, matched with 15 volunteers. FA and MD were
calculated from tractography images at the C2-C3 level and compressed level in patients and at the C2-C3 and C4-C7 in controls.
Patients were clinically evaluated using a self-administered questionnaire.
Results
The FA values of patients were significantly lower at the compressed level than the FA of volunteers at the C4-C7 level. A
significant positive correlation between FA at the compressed level and clinical assessment was demonstrated. Increased signal
intensity on T2-weighted images did not correlate either with FA or MD values, or with any of the clinical scores.
Conclusion
FA values were significantly correlated with some of the patients’ clinical scores. High signal intensity of the spinal cord
on T2 was not correlated either with the DTI parameters or with the clinical assessment, suggesting that FA is more sensitive
than T2 imaging.
Keywords Diffusion tensor imaging – Cervical spondylosis – Tractography – Clinical correlation – Fractional nisotropy