Our orientation regarding the dementias has changed during the past 30 yr. For example, in the not too distant past, illnesses such as Alzheimer’s disease (AD) and Pick’s disease were believed to be rare, if not obscure, illnesses (1). This viewpoint is juxtaposed to contemporaneous ideas put forth by Katzman and colleagues (2) who believed that AD was not only prevalent but represented a major public health problem. During the past 10 yr, the diagnosis of dementia has become increasingly complex, requiring the consideration of an array of conditions, including AD, vascular dementia (VaD), dementia with Lewy body (DLB), frontal-temporal dementia (FTD), cortical basilar degeneration (CBD), and subcortical dementias, such as progressive supernuclear palsy (PSP) and Parkinson’s disease.