Teaching diabetes self-management to the growing number of hospitalized patients with diabetes and hyperglycemia is a challenging task. Inpatients are acutely ill and in an environment that is fraught with frequent interruptions and other concerns related to the admitting diagnosis. Because of these competing priorities, limited time, and an ill-conducive learning environment, the primary focus for diabetes self-management education should be on those skills that are essential for the patient to be able to return home safely. This chapter explores the inpatient diabetes self-management education process including assessment, identifying barriers and advantages, goal setting, key topics of content, delivery, communication among providers, and discharge. Practical tips are offered to help integrate diabetes self-management education into current clinical practice in the inpatient setting.