This study sought to validate World Wide Web-compliant software tools used to collect health-related quality of life (HRQOL) data, relative to pencil-and-paper collection. The RAND-36 general health survey and the Seattle Angina questionnaire (SAQ), a disease-specific functional status measure for patients with coronary artery disease, were each administered in paper and electronic format to 55 consecutive patients visiting the cardiology outpatient clinic of a public hospital. All eight sub-scale scores of the RAND-36 (interclass correlation coefficient range = 0.54–0.75, p < 0.01)="" and="" all="" five="" domains="" of="" the="" saq="" (interclass="" correlation="" coefficient="" range="0.84–0.90,">p < 0.01)="" collected="" using="" the="" software="" were="" significantly="" correlated="" with="" those="" collected="" using="" the="" paper="" version="" of="" questionnaires.="" computer="" literacy,="" educational="" level,="" age,="" sex,="" and="" race="" were="" not="" significantly="" associated="" with="" the="" ability="" to="" successfully="" complete="" the="" computer-assisted="" questionnaire.="" eighty-two="" percent="" of="" patients="" preferred="" the="" computer-assisted="" administration="" to="" paper,="" and="" 89%="" reported="" that="" they="" would="" feel="" comfortable="" using="" the="" software="" in="" the="" future="" without="" any="" technical="" assistance.="" this="" pilot="" study="" suggests="" that="" hrqol="" measures="" can="" be="" reliably="" collected="" using="" software="" operating="" over="" the="" world="" wide="" web.="" data="" collected="" in="" this="" manner="" are="" valid="" and="" of="" comparable="" quality="" to="" self-reported,="" hrqol="" data="" obtained="" via="" paper="">