Injection of 10 mg/kg tetrabenazine in castrated male rats, treated with daily injections of 50
g/kg estradiol benzoate, resulted in lordosis behavior in the majority of the animals. Nialamide (50 mg/kg) antagonized the effect of tetrabenazine. It was suggested that the occurrence of the lordosis pattern in estrogen pretreated rats is related to levels of monoamines.
Key-Words Male Rat - Lordosis - Estrogen - Tetrabenazine - Nialamide
This work was supported by National Institute of Health, Division of Child Health and Human Development, Grant HD 00344, Swedish Council for Social Research and Riksbankens Jubileumsfond.The drugs were generously supplied by Hoffmann-La Roche (Tetrabenazine Nitoman ®) and Pfizer (Nialamide ®).
For estrogen and progesterone we thank Organon, The Netherlands.
Skillful technical assistance was provided by Miss Lena Mjöberg and Mr. Lars Eriksson.