A preparative synthesis of 2,5-disubstituted 1,3,4-oxadiazoles by the reaction of trichloromethylarenes with hydrazides of carboxylic acids of the aliphatic, aromatic and heteroaromatic series in methanol or ethanol in the presence of pyridine was developed.
N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 117913. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 686–692, May, 1994. Original article submitted April 8, 1994.